248 research outputs found

    The Ecology of Paradox: Disturbance and Restoration in Land and Soul

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    This heuristic study explores environmental disturbance and ecological restoration in several North American settings in order to uncover epistemological, philosophical, aesthetic and ethical considerations revolving around those place-based processes. With fire as one of the central metaphors of this work, the initial place-based chapter examines Northern New Mexico\u27s Pajarito Plateau to explore the region\u27s fire ecology. The study then moves to the Pacific Northwest to draw restoration practice that attempt to restore wild salmon to urban Seattle habitat. The third place-based chapter focuses on the Midwest grass and farmlands in order to investigate the seeming contradictions between commodity and diversity in prairie landscapes. In the final chapter, the metaphorical implications of disturbance and restoration are explored in terms of individuals, communities and as a society. In explicating the philosophical and phenomenological foundations of disturbance and restoration, personal experiences are used in the study as examples to develop applied practice of paradox. It also examines and illuminates correspondences between ecological and eco-psychological cycles of disturbance and restoration within the context of paradox, which for the purpose of this work is defined as any place or context where seemingly contradictory elements coexist without canceling each other out. Drawing from place and literary sources, the study seeks to extrapolate a metaphorical correspondence in exterior and interior realms of paradox. The conclusion is that attention to processes of disturbance and restoration in nature can yield wisdom that informs our relationships with our ecological surroundings, our communities, and our individual selves. Furthermore, specific practices can emerge to help humans deal more healthfully and strategically with the complex, divisive issues of our places and times

    The Ecology of Paradox: Disturbance and Restoration in Land and Soul

    Get PDF
    This heuristic study explores environmental disturbance and ecological restoration in several North American settings in order to uncover epistemological, philosophical, aesthetic and ethical considerations revolving around those place-based processes. With fire as one of the central metaphors of this work, the initial place-based chapter examines Northern New Mexico\u27s Pajarito Plateau to explore the region\u27s fire ecology. The study then moves to the Pacific Northwest to draw restoration practice that attempt to restore wild salmon to urban Seattle habitat. The third place-based chapter focuses on the Midwest grass and farmlands in order to investigate the seeming contradictions between commodity and diversity in prairie landscapes. In the final chapter, the metaphorical implications of disturbance and restoration are explored in terms of individuals, communities and as a society. In explicating the philosophical and phenomenological foundations of disturbance and restoration, personal experiences are used in the study as examples to develop applied practice of paradox. It also examines and illuminates correspondences between ecological and eco-psychological cycles of disturbance and restoration within the context of paradox, which for the purpose of this work is defined as any place or context where seemingly contradictory elements coexist without canceling each other out. Drawing from place and literary sources, the study seeks to extrapolate a metaphorical correspondence in exterior and interior realms of paradox. The conclusion is that attention to processes of disturbance and restoration in nature can yield wisdom that informs our relationships with our ecological surroundings, our communities, and our individual selves. Furthermore, specific practices can emerge to help humans deal more healthfully and strategically with the complex, divisive issues of our places and times

    Use of a Semi-field System to Evaluate the Efficacy of Topical Repellents under user Conditions Provides a Disease Exposure free Technique Comparable with Field Data.

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    Before topical repellents can be employed as interventions against arthropod bites, their efficacy must be established. Currently, laboratory or field tests, using human volunteers, are the main methods used for assessing the efficacy of topical repellents. However, laboratory tests are not representative of real life conditions under which repellents are used and field-testing potentially exposes human volunteers to disease. There is, therefore, a need to develop methods to test efficacy of repellents under real life conditions while minimizing volunteer exposure to disease. A lotion-based, 15% N, N-Diethyl-3-methylbenzamide (DEET) repellent and 15% DEET in ethanol were compared to a placebo lotion in a 200 sq m (10 m x 20 m) semi-field system (SFS) against laboratory-reared Anopheles arabiensis mosquitoes and in full field settings against wild malaria vectors and nuisance-biting mosquitoes. The average percentage protection against biting mosquitoes over four hours in the SFS and field setting was determined. A Poisson regression model was then used to determine relative risk of being bitten when wearing either of these repellents compared to the placebo. Average percentage protection of the lotion-based 15% DEET repellent after four hours of mosquito collection was 82.13% (95% CI 75.94-88.82) in the semi-field experiments and 85.10% (95% CI 78.97-91.70) in the field experiments. Average percentage protection of 15% DEET in ethanol after four hours was 71.29% (CI 61.77-82.28) in the semi-field system and 88.24% (84.45-92.20) in the field. Semi-field evaluation results were comparable to full-field evaluations, indicating that such systems could be satisfactorily used in measuring efficacy of topically applied mosquito repellents, thereby avoiding risks of exposure to mosquito-borne pathogens, associated with field testing

    Early respiratory viral infections in infants with cystic fibrosis

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    This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Background Viral infections contribute to morbidity in cystic fibrosis (CF), but the impact of respiratory viruses on the development of airway disease is poorly understood. Methods Infants with CF identified by newborn screening were enrolled prior to 4 months of age to participate in a prospective observational study at 4 centers. Clinical data were collected at clinic visits and weekly phone calls. Multiplex PCR assays were performed on nasopharyngeal swabs to detect respiratory viruses during routine visits and when symptomatic. Participants underwent bronchoscopy with bronchoalveolar lavage (BAL) and a subset underwent pulmonary function testing. We present findings through 8.5 months of life. Results Seventy infants were enrolled, mean age 3.1 ± 0.8 months. Rhinovirus was the most prevalent virus (66%), followed by parainfluenza (19%), and coronavirus (16%). Participants had a median of 1.5 viral positive swabs (range 0–10). Past viral infection was associated with elevated neutrophil concentrations and bacterial isolates in BAL fluid, including recovery of classic CF bacterial pathogens. When antibiotics were prescribed for respiratory-related indications, viruses were identified in 52% of those instances. Conclusions Early viral infections were associated with greater neutrophilic inflammation and bacterial pathogens. Early viral infections appear to contribute to initiation of lower airway inflammation in infants with CF. Antibiotics were commonly prescribed in the setting of a viral infection. Future investigations examining longitudinal relationships between viral infections, airway microbiome, and antibiotic use will allow us to elucidate the interplay between these factors in young children with CF
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